EGFR/kinKDR peptide substrate EEPLYWSFPAKKK-amide

Description

EGFR/kinKDR peptide substrate of epidermal growth factor receptor (EGFR) which when dysregulated can contribute towards many diseases such as cancer

See full description

Catalogue number crb1001421
Sequence (one letter code) EEPLYWSFPAKKK-amide
Sequence (three letter code) H-Glu-Glu-Pro-Leu-Tyr-Trp-Ser-Phe-Pro-Ala-Lys-Lys-Lys-NH2
Purity >95%
Storage -20°C
Molecular Weight 1620.9
References

Wieduwilt and Moasser (2011) The epidermal growth factor receptor family: Biology driving targeted therapeutics. Cell Mol. Life Sci. 65(10) 1566 PMID: 18259690

 

Xie et al (2011) AST1306, A Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both In Vitro and In Vivo. PLoS One 6(7)  e21487 PMID: 21789172

 

Rudolf  (2014) A Comparison of Protein Kinases Inhibitor Screening Methods Using Both Enzymatic Activity and Binding Affinity Determination.  PLOS One 9(6) e98800. PMID: 24915177

Substrate of the epidermal growth factor receptor (EGFR), a member of the receptor tyrosine kinase family known as ErbBs or HER receptors. These receptors are involved in the regulation of cell proliferation, survival, differentiation and migration. However their dysregulation can contribute towards many diseases such as cancer.

Binding to the ligand binding domain of the EGFR causes receptor dimerization. This is sequentially followed by the tyrosine kinase domain being activated and the tyrosines on the C-terminal tail become phosphorylated, which in turn activates downstream signalling pathways.

EGFR/kinKDR peptide substrate

Cat No. Pack Size Price Qty

crb1001421h

0.5mg

$127.50

crb1001421j

1mg

$165.00