Acetyl-TGF-beta 2-LAPβ (259– 269) Acetyl-YTSGDQKTIKS-amide


Transforming growth factor beta 2-latency- associated peptide LAPβ a non-lysosomal glycoprotein with mannose 6-phosphate (Man-6-P) residues on its N-glycans

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Catalogue number crb1000322
Sequence (one letter code) Acetyl-YTSGDQKTIKS-amide
Sequence (three letter code) Acetyl-Tyr-Thr-Ser-Gly-Asp-Gln-Lys-Thr-Ile-Lys-Ser-NH2
Purity >95%
Molecular Weight 1267.6
References Barnes et al., (2012). Latency-associated Peptide of Transforming Growth Factor-β1 Is Not Subject to Physiological Mannose Phosphorylation. J Biol Chem. 287(10): 7526. PMID: 22262853
Latent TGF-β1 is a non-lysosomal glycoprotein with mannose 6-phosphate (Man-6-P) residues on its N-glycans.

When it is released, latent TGF-β1 is bound to its latency-associated peptide (LAP), it must then be activated and released from LAP before it can bind to its cell surface-localised Man-6-P receptors and exert its biological activity. Activation can occur by various mechanisms in vivo, including those governed by integrins and thrombospondin. Mannose phosphorylation has also been implicated in this activation process. Man-6-P has been proposed as an anti-scarring therapy due to its ability to directly block the activation of latent TGF-β1.

Acetyl-TGF-beta 2-LAPβ (259– 269)

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