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Huang et al (1996) The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product. PNAS USA 93(18) 9730 PMID: 8790399
Probst et al (2017) Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8+T-cell Recognition of a Retroviral Antigen. Cancer Res. 77(13) 3644 PMID: 28484076
The AH1 peptide is a H2-Ld-restricted epitope derived from the sequence of the gp70 envelope protein of the ecotropic mammalian C-type retrovirus, murine leukaemia virus (MuLV, emv-1).
The envelope gene products of MuLV are expressed in a variety of tumour cells, including B16 melanoma, lymphomas and leukaemia’s. AH1 peptide is a tumour-associated antigen and is highly expressed on CT26 and C51 tumour cells
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