T peptide Ac-vqlvykRRRRRRRRR-amide

Description

Cell permeable peptide where the amyloid forming sequence is homologous to a nucleating sequence from the human Tau protein (306VQIVYK311). Forms long lived oligomers that are taken up by endocytosis and is cytotoxic in multiple cell lines.  Co-localizes with pathological hyperphosphorylated forms of Tau in vitro. 

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Catalogue number crb1001356
CAS 2022956-62-1
Sequence (one letter code) Ac-vqlvykRRRRRRRRR-amide
Sequence (three letter code) Acetyl-dVal-dGln-dLeu-dVal-dTyr-dLys-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-NH2
Modifications Where lowercase indicates D-amino acids, Nine arginines have been attached for cell permeability
Disease Area Alzheimers
Research Area Neuroscience
Purity >95%
Storage -20°C
Molecular Weight 2194.4
References

Veloria et al (2017)  Novel Cell Model for Tauopathy Induced by a Cell-Permeable Tau-Related Peptide.  ACS Chemical Neuroscience 8 2734. PMID:28837764

Cell permeable peptide where the amyloid forming sequence is homologous to a nucleating sequence from the human Tau protein (306VQIVYK311). Forms long lived oligomers that are taken up by endocytosis and is cytotoxic in multiple cell lines.  Co-localizes with pathological hyperphosphorylated forms of Tau in vitro. 

T peptide

Cat No. Pack Size Price Qty

crb1001356h

0.5mg

$112.50

crb1001356j

1mg

$150.00