XL 13m Ac-ARK(X)-amide

Description

Inhibits the epigenetic reader YEATS domain of the Eleven-nineteen leukemia (ENL) protein and perturbs the recruitment of ENL onto chromatin. Induces downregulation of a set of genes that are essential for leukemogenesis and leukaemia maintenance.

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Catalogue number crb1001368
Sequence (one letter code) Ac-ARK(X)-amide
Sequence (three letter code) Ac-Ala-Arg-Lys-(X)-NH2, Where X is oxazole-5-carboxylic acid
Disease Area Cancer (leukaemia)
Research Area Epigenetics, protein-protein interactions
Purity >95%
Storage -20°C
Molecular Weight 509.3
References

Li et al (2018) Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking. Nat Chem Biol. 14, 1140. PMID: 30374167

Inhibits the epigenetic reader YEATS domain of the Eleven-nineteen leukemia (ENL) protein and perturbs the recruitment of ENL onto chromatin. Induces downregulation of a set of genes that are essential for leukemogenesis and leukaemia maintenance.

XL 13m

Cat No. Pack Size Price Qty

crb1001368h

0.5mg

$112.50

crb1001368j

1mg

$150.00